bupropion hydrochloride is a norepinephrine and dopamine reuptake inhibitor. It has both reuptake inhibition and dopamine-activating properties. Long-term high-dose bupropion in patients can down-regulate b-adrenoceptors. bupropion hydrochloride is used for bipolar depression, delayed depression, hypersomnia, cognitive slowness or pseudo-dementia and serotonin and other drugs ineffective or intolerable. It can also be used for attention deficit disorder, smoking cessation, and stimulant withdrawal. fatigue and craving, while restlessness, insomnia, headache, nausea and sweating are common adverse drug side effects