Linagliptin CAS 668270-12-0
Port: Shanghai, China
|Standard packing material||Aluminum foil bag inside, then waterproof bag or carton|
|Storage||Preserve in tight,light-resistant containers in a cool place|
Linagliptin is a DPP-4 inhibitor developed by Boehringer Ingelheim for treatment of type II diabetes.
Linagliptin was approved by the U.S. Food and Drug Administration (FDA) on 2 May 2011 for treatment of type II diabetes.
Linagliptin is a kind of dipeptide peptidase 4 (DPP – 4) inhibitors used as dietary and exercise in type 2 diabetes in adult auxiliary treatment to improve blood sugar control.
Linagliptin is used with a proper diet and exercise program and possibly with othermedications to control high blood sugar. It is used by people with type 2 diabetes. Controlling high blood sugar helps prevent kidney damage, blindness, nerve problems, loss of limbs, and sexual function problems. Proper control of diabetes may also lessen your risk of a heart attack or stroke.
1. Incretin (Incretin) has the role of intestinal promoting insuli n B cells to secrete insuli n, mainly including glucose-dependent insuli notropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1). DDP-4 is a serine protease located on the cell surface, which is widely found in plasma and in vivo tissues (such as kidney, liver, small intestine villi, endothelial cells, etc.). Rilalitine is a selective DPP-4 inhibitor that inhibits the activity of the enzyme by reversibly binding to DPP-4, delays GLP-1 degradation, enhances GLP-1 activity, and stimulates glucose-dependent Insuli n secretion, and reduce circulating levels of glucagon, thereby regulating blood glucose levels in patients with type 2 diabetes.
2. Compared with other DPP-4 inhibitors, the main advantages of liradetine is: with excellent renal safety, and can effectively reduce glycosylated hemoglobin. Lilardine mainly in the form of excretion of fecal excretion, the oral administration, the amount of renal excretion is only 5% of the dose, even if the intravenous administration, and only 30.8% of the excretion by the kidney, so the patient did not need treatment Regularly check the liver, kidney function and dose adjustment, all patients can be a unified fixed dose, easy to prescribe.
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