Estradiol valerate (Estradiol valerate) is the valerate ester of estradiol, which has a similar effect to estradiol. It is a long-acting estrogen preparation that can be maintained for 2 weeks after injection. It has positive feedback and negative feedback regulation on the hypothalamus-pituitary gland, which indirectly affects the development of follicles and ovulation; promotes the development of female sexual organs and secondary sexual characteristics; promotes endometrial hyperplasia and repair, and promotes cervical gland epithelial cell proliferation. Increase the secretion of cervical mucus to help sperm penetrate. It can improve menopausal symptoms and reduce the occurrence of osteoporosis and cardiovascular disease in postmenopausal women.