Procaine hydrochloride is white fine needle crystal or crystalline powder at room temperature, odorless, slightly bitter and numb in taste, easily soluble in water, soluble in ethanol, slightly soluble in chloroform, and almost insoluble in ether. The ester bond in the procaine hydrochloride structure can be hydrolyzed to generate p-aminobenzoic acid Chemicalbook and diethylaminoethanol. Under certain conditions, p-aminobenzoic acid can be further decarboxylated to generate toxic aniline. Procaine hydrochloride has an aromatic primary amino group in its structure, which is easy to oxidize and discolor. pH value, temperature, ultraviolet light, oxygen and metal ions can accelerate oxidation discoloration.
procaine hcl is a sodium channel, NMDA receptor and acetylcholine receptor inhibitor with IC50 of 60 μM, 0.296 mM and 45.5 μM, respectively, and a 5-HT3 inhibitor with KD of 1.7 μM.