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orlistat supplement Combining a low-calorie diet is indicated for the long-term treatment of obese and overweight individuals, including those who have developed obesity-related risk factors. orlistat supplement Has long-term weight control (weight loss, weight maintenance and rebound prevention) efficacy. Taking Xenical may reduce risk factors associated with obesity and the incidence of other obesity-related diseases, including hypercholesterolemia and type 2 diabetes.