Factory price supply of melatonin pine nuts health care raw materials, Powder: Yes Certification: GMP, HSE, ISO 9001, USP, BP State: Powder Purity: >99% Name:melatonin

Precautions while taking melatonin
1. Strictly follow the people who take it, the dosage and the time of taking it.
2. Don’t be superstitious about imported melatonin products. Melatonin is a health food. Whether it is a domestic or foreign imported raw material, as long as the quality standard is qualified, the effect of taking melatonin is the same.
3, taking melatonin can not take aspirin at the same time.
4. It is best not to smoke when taking melatonin, because smoking can destroy melatonin. Also, don’t drink a lot.
5. The health care function of melatonin approved by the Ministry of Health is only to improve sleep function, and the literature reports on other health care functions of melatonin need to be further verified.

unsuitable people
Melatonin does have a good effect on improving sleep and immune regulation, but it is not suitable for everyone, and taking it improperly is counterproductive. The following people should take melatonin with caution.
1. Minors
2. Pregnant women
3. Patients with heart and brain disease
4. Liver and kidney insufficiency
5. Those who are allergic to alcohol

The main purpose
anti aging
Free radicals may be generated during enzymatic and non-enzymatic reactions in the body, and free radicals are closely related to aging. The generation and elimination of free radicals in the normal body are in a dynamic balance. Once this balance is broken, free radicals will cause damage to biological macromolecules such as lipids, proteins, and nucleic acids, resulting in the destruction of cell structures and the aging of the body. Melatonin protects cell structure, prevents DNA damage, and reduces peroxide levels in the body by scavenging free radicals, anti-oxidation and inhibiting lipid peroxidation. The study by Russel et al. found that melatonin protected 99% of DNA damage caused by safrole, a carcinogen that damages DNA by releasing free radicals, in a dose-response relationship. Melatonin has obvious antagonistic effect on the peroxidation caused by exogenous toxins (such as paraquat) and the tissue damage caused by free radicals. Melatonin can also reduce the content of LPO in the brain, and its effects are basically the same in different areas of the brain, such as the cerebral cortex, cerebellum, hippocampus, hypothalamus, striatum, etc., and all are in a dose-dependent manner. But different strains of rats such as Sprague-Dawlay and Wistar rats have different sensitivity to melatonin.

fight tumor
In vitro studies by Vijayalaxmi et al. (1995) found that melatonin had a significant protective effect on the chromosomal damage of human peripheral lymphocytes caused by γ-rays (150cGy) of 137Cs, and showed a dose-response relationship; physical and chemical effects on free radicals Mutagenicity and carcinogenicity are antagonistic. In vitro experiments have shown that melatonin also has a protective effect on the mutagenicity caused by self-immobilization C. Melatonin reduces the formation of DNA adducts induced by chemical carcinogens (safrole) and prevents DNA damage. Jianjun Yan et al. studied the anti-tumor effect of melatonin on H22 liver cancer mice, and found that it can inhibit the tumor growth and prolong the survival time of tumor-bearing mice, and has obvious synergy with IL-2. Danforth et al measured the 24-hour plasma melatonin levels of women in normal, breast cancer, and breast cancer-prone patients, respectively, and found that normal women had a circadian rhythm; the circadian rhythm of breast cancer patients was significantly related to the amount of steroid receptors in the primary tumor related. In patients with positive estrogen (ER) or progesterone (PR) receptors, the mean day-to-night plasma melatonin level was significantly lower than that in patients with ER or PR negative tumors, and was significantly negatively correlated with the amount of ER or PR receptors in the primary tumor , indicating that melatonin has a certain correlation with hormone-dependent human breast cancer. Melatonin promotes endogenous granulocyte/macrophage-promoting accumulation factor production by myeloid T-cells and can be used as an adjuvant therapy for tumors.

sleep
It can shorten the time to wake up before going to bed and the time to fall asleep, the quality of sleep, the number of awakenings during sleep are significantly reduced, the light sleep stage is shortened, the deep sleep stage is prolonged, and the wake-up threshold the next morning decreases. There is a strong function of adjusting the time difference. [1] Mainly used in whitening and moisturizing cosmetics, and also commonly used in hair growth products. Extensive research has been carried out on the biological functions of melatonin at home and abroad, especially as a dietary supplement, and it has been shown that it has many physiological functions such as promoting sleep, regulating jet lag, anti-aging, regulating immunity, and anti-tumor. The health care function of melatonin at home and abroad involves regulating endocrine (suppressing ovulation), protecting against encephalitis virus infection, reducing mortality after infection, AIDS treatment and cardiovascular protection.