cannabidiol for pain lowest:Medical application: Analgesic and anti-inflammatory: Cannabidiol can produce analgesic effect. The pharmacological mechanism of analgesia is mainly related to CB1 receptor and CB2 receptor. CB1 receptors achieve analgesic effects by directly inhibiting the release of γ-aminobutyric acid (GABA) in the midbrain periaqueductal gray matter and RVM and glutamate in the spinal cord. CB2 receptor inhibits allergic inflammation by weakening the degranulation of mast cells and neutrophil aggregation induced by nerve growth factor, and thereby mediates immunosuppressive effects, achieving anti-inflammatory and analgesic effects, and the effect is stronger than well-known and The widely used aspirin. [2]
Anti-epileptic: The GABA neurotransmitter in the human brain has a calming effect and inhibits the excitability of the brain center. Cannabidiol can help control the consumption of GABA neurotransmitter, inhibit brain excitement, reduce seizures, and can also help improve the efficacy of other anti-epileptic drugs. [2]
Anti-anxiety: Endogenous cannabidiol is an important substance that helps depression patients reduce anxiety and exists in the human body. Cannabidiol can help endocannabinoids to be maintained at a reasonable level, allowing patients to feel good and happy, without being addictive like THC.