API Cefaclor CAS 53994-73-3 cefaclor antibacterial

API Cefaclor CAS 53994-73-3

Port:Shenzhen, China
Transport Package:Aluminum Foil Bag Inside, Then Waterproof Bag or
Payment Terms:T/T, D/P, Western Union, Paypal,
Powder: Yes
Certification: GMP, HSE, ISO 9001, USP, BP
State: White Powder
Purity: >99%
Name: Ceftazidime
Color: White Color

Product name	cefaclor
Melting point	102-104°C
Boiling point	713.4 ºC
density	1.62 g/cm³
Chemical Properties	White Solid
storage temp	-20°C

Cefaclor (cefaclor), chemical name (6R,7R)-7-[(R)-2-amino-2-phenylacetamido]-3-chloro-8-oxo-5-thia-1-nitrogen Heterobicyclo[4.2.0]oct-2-ene-2-carboxylic acid, chemical formula is C15H14ClN3O4S, white to light yellow powder or crystalline powder, slightly odor, slightly soluble in water, in methano l, ethanol, trichloromethane or dichloromethan e Almost insoluble in methyl chloride. Cefaclor is a β-lactam antibiotic and cephalosporin. It is a second-generation cephalosporin. It is mainly used for acute pharyngitis, acute tonsillitis, otitis media, bronchitis, pneumonia and other respiratory infections caused by sensitive bacteria. , Skin and soft tissue infections and urinary tract infections.

Cefaclor is mainly suitable for acute pharyngitis, acute tonsillitis, otitis media, bronchitis, pneumonia and other respiratory infections, skin and soft tissue infections and urinary tract infections caused by sensitive bacteria

A method for the synthesis of cefaclor using 7-amino-3-chlorinated cefacoalkanic acid and phenylglycine deng salt (ethyl sodium salt) as starting materials in a two-step process, characterized by the following steps:

1) mixed anhydride solution (mixed anhydride) was obtained by dissolving phenylglycine deng salt (ethyl sodium salt) and terpenyl chloride (trimethylacetyl chlorid e) in polar aprotic organic solvent under the action of pyridin e catalyst.

2) 7-acca forms salt with nitrogenous organic base and dissolves in polar aprotic organic solvent to obtain 7-acca solution;

3) acylation condensation reaction was carried out between 7-acca solution and mixed anhydride under the condition of pyridin e catalyst, and inorganic acid was added into the solution for hydrolysis, and the aqueous solution of cefaclor and acid salt was obtained by phase separation;

4) adding DMF or DMAC into the aqueous solution of cefaclor and acid salt to prepare cefaclor DMF or DMAC solvents under the condition of adding alkali;

5) cefaclor was obtained by conversion of DMF or DMAC solvents in aqueous and aqueous homogeneous organic solutions. The yield of cefaclor DMF complex reached 90%, and the total yield reached over 82%.

Application
Antibiotics. The antibacterial effect is stronger than cefalexin. It is mainly used for urinary tract infection, upper respiratory tract infection, skin and soft tissue infection and ent infection.